Lillian

LDL alternative splicing



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kunkel@med.harvard.edu


 * Most Promising**


 * 1. Nanocapsules for Drug Delivery**

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naturally occurring mutation nothing wrong with the people phenotypically problem: mechanism unknown
 * 2. ANGPTL3 for lowering LDL, HDL, and triglycerides**




 * Initial Search**



"vaccine-potential of fHbp for prevention of meningococcal epidemics"

"Due to the central role that factor H plays in the regulation of complement, there are a number of clinical implications arrising from aberrant factor H activity. Overactive factor H may result in reduced complement activity on pathogenic cells - increasing susceptibility to microbial infections. Underactive factor H may result in increased complement activity on healthy host cells - resulting in autoimmune diseases. It is not surprising therefore that [|mutations] or [|single nucleotide polymorphisms] (SNPs) in factor H often result in pathologies. Moreover the complement inhibitory activities of factor H, and other complement regulators, are often used by pathogens to increase [|virulence] ."



new HIV vaccine seems to be 50% effective in rhesus monkeys uses a CMV vector to deliver proteins



Recombinant IL-2/diphtheria toxin fusion protein (rIL-2/DTx), a drug that is FDA-approved for the treatment of cutaneous T cell lymphoma, has been reported to deplete regulatory CD4+ T cells.

These data suggest that pharmacological suppression of immune counterregulation using a commercially available drug originally developed for cancer therapy may have practical therapeutic utility in leishmaniasis. Rational reinvestigation of the efficacy of drugs approved for other indications in experimental models of neglected tropical diseases has promise in providing new candidates to the drug discovery pipeline.



Acute renal failure is one of the most serious complications of envenoming resulting from //Crotalus durissus terrificus // bites. This study evaluated the relevance of hyperuricemia and oxidative stress and the effects of allopurinol and probenecid in renal dysfunction caused by direct nephrotoxicity of //C. d. terrificus //venom.

allopurinol deserves to be clinically evaluated as an approach complementary to anti-snake venom serotherapy.

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Encapsulation of the flavonoid quercetin with an arsenic chelator into nanocapsules enables the simultaneous delivery of hydrophobic and hydrophilic drugs with a synergistic effect against chronic arsenic accumulation and oxidative stress

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"delivery system suitable for drug delivery to target organs, most importantly the brain, which is the ultimate challenge in drug delivery."

demonstrates the synergistic potency of oral application of the flavonoid QC with DMSA in a nanocapsulated form against p53-mediated hepatic and cerebral cell death in response to chronic arsenic consumption.

Our study evidently demonstrates that a combination of QC and DMSA in a nanocapsulated drug delivery system is most effective in reducing the arsenic burden in liver and brain, protected liver from arsenic-induced fibrosis, safeguarded cells from ROS-induced damage, restored mitochondrial integrity, and down-regulated ROS-induced signaling pathways that lead the cells toward p53-dependent apoptosis. This demonstration of the nanoparticulated formulation of N(QC+DMSA) and evaluation of its efficacy in conferring protection to neuronal and hepatic mitochondria in an experimental model of chronic arsenic consumption in rats provide a “lead” in the search for orally deliverable curatives for the “silent killer” arsenic.


 * enables the simultaneous delivery of hydrophobic and hydrophilic drugs**

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 * Intranasal Insulin for Alzheimer's Disease**